The first early human eggs from stem cells

(conception.bio)

51 points | by dsr12 1 hour ago

4 comments

  • gnabgib 1 hour ago
    Related (2021) Turning stem cells into human eggs (97 points, 102 comments) https://news.ycombinator.com/item?id=29040823
  • misiek08 34 minutes ago
    How hard you have to work to break scroll on web page? Nice article, but going through it was a technical nightmare.

    Can we stop adding unnecessary JS to website to stop global warming by calculating AND ALTERING SCROLL?

    • happymellon 7 minutes ago
      Odd. It was a designers dream (and a readability nightmare) but I didn't have an issue with scroll.

      Firefox on Samsung S23, not exactly a new or a powerful phone but rendered it fine.

    • sudo_cowsay 16 minutes ago
      Good idea in theory but terribly impractical in practice.
  • scotty79 20 minutes ago
    That can't be good. Life cycle of a human egg is organized around preserving mitochondria to be as young and fresh as possible across generations. Using adult cell, even a stem cell to make an egg probably gives it mitochondrial damage that usually takes hundreds of human generations to accumulate.
    • Protostome 3 minutes ago
      Mitochondria can be translplanted/replaced. There already therapies and babies born out of these kinds of procedures
    • Jackobrien 6 minutes ago
      Really interesting point if true. Makes sense to me, and I’m sure the team is trying to solve it
    • treyd 9 minutes ago
      I wonder if you could coax cells from the testes back into stem cells to then re-specialize into ovarian cells.
    • rf15 9 minutes ago
      genuinely curious: how does any life still exist if this holds true?
  • shevy-java 1 hour ago
    A japanese scientist again (Katsuhiko Hayashi is in Osaka).

    Shinya Yamanaka created iPSPs in 2009:

    https://en.wikipedia.org/wiki/Shinya_Yamanaka

    Guess the japanese excel at micromanaging. Although one could say that the research here in the article is more epic than Shinya's discovery, but I remember having watched one of his presentation and it convinced me of pure epicness, if you understand how his team found the "Yamanaka factors". That was by human (work) consistency. About as epic as Christiane Nüsslein-Volhard and her mutant screens, that also involved tons of micro-experiments.